WhatPeptide

GHRP-2

A potent synthetic GH secretagogue with human endocrine data demonstrating acute GH pulse stimulation.

Moderate evidence Unregulated Growth Hormone Releasing Peptide

Written by WhatPeptide Editorial Team · Last updated 2026-03-17

Half-life

About 30 minutes

Dosage range

100-300 mcg one to three times daily (published research context)

Administration

Subcutaneous injection

Research level

Moderate

How GHRP-2 works

GHRP-2 activates GHSR-1a to trigger GH secretion and may synergize with GHRH signaling at the pituitary. It can also increase ACTH/cortisol in some settings relative to more selective agents. Most evidence focuses on endocrine responses rather than long-term outcomes.

Also known as: KP-102, Pralmorelin

Research relevance

GH Boost
Strong research relevance 80
Muscle Growth
Moderate relevance 75
Recovery & Healing
Moderate relevance 55
Anti-Aging & Longevity
Moderate relevance 55
Fat Loss
Moderate relevance 50
Sleep & Relaxation
Moderate relevance 50
Injury Rehab
Some relevance 25
Cognition & Focus
Some relevance 20
Hair & Skin
Some relevance 20
Sexual Health
Some relevance 20

Side effects & safety

Increased appetite Water retention Flushing Fatigue Elevated IGF-1 — theoretical concern for cancer promotion with prolonged use Possible insulin resistance with chronic use

Contraindications

Pregnancy
History of hormone-sensitive cancer
Uncontrolled diabetes

Consult a healthcare provider before use if any of these apply to you.

Key studies

FAQ

What is GHRP-2? +
A potent synthetic GH secretagogue with human endocrine data demonstrating acute GH pulse stimulation. Its mechanism of action is supported by moderate clinical and preclinical evidence.
What is GHRP-2 researched for? +
GHRP-2 has the strongest research relevance for GH Boost, Muscle Growth, Recovery & Healing. Evidence is supported by moderate clinical and preclinical evidence.
What are the side effects of GHRP-2? +
Reported side effects include Increased appetite, Water retention, Flushing, Fatigue, Elevated IGF-1 — theoretical concern for cancer promotion with prolonged use, Possible insulin resistance with chronic use. Key contraindications: Pregnancy; History of hormone-sensitive cancer; Uncontrolled diabetes.
Is GHRP-2 FDA approved? +
GHRP-2 is not FDA-approved. It is available as a research compound or through compounding pharmacies in some jurisdictions.
How is GHRP-2 administered? +
GHRP-2 is typically administered via subcutaneous route. Researched dosage range: 100-300 mcg one to three times daily (published research context). Half-life: About 30 minutes.

Explore similar peptides

GHRP-6

Moderate evidence

Growth Hormone Releasing Peptide

An early GH secretagogue peptide commonly associated with increased appetite alongside GH pulse stimulation.

Hexarelin

Moderate evidence

Growth Hormone Releasing Peptide

Hexarelin is a synthetic hexapeptide GHRP and one of the most potent GH secretagogues, also studied for cardioprotective properties through ghrelin receptor-independent mechanisms. It demonstrates GH-releasing activity comparable to GHRP-6 but with distinct cardiovascular effects observed in animal models.

Ipamorelin

Moderate evidence

Growth Hormone Releasing Peptide

A selective ghrelin-receptor agonist studied for stimulating GH release with less prolactin/cortisol impact than older GHRPs. Originally placed on FDA Category 2 list (September 2023), then removed September 27, 2024 when the nominator withdrew. FDA still lists it under 'Other bulk drug substances that may present significant safety risks.' Regulatory status remains uncertain.