WhatPeptide

HCG

Human Chorionic Gonadotropin (HCG) is an FDA-approved glycoprotein hormone used clinically to stimulate testosterone production in hypogonadal men, support fertility in women, and maintain testicular function during or after androgen therapy. It mimics luteinizing hormone (LH) at the gonadal level.

Strong evidence FDA Approved Hormonal

Written by WhatPeptide Editorial Team · Last updated 2026-03-17

Half-life

Approximately 29 hours SC, 26.5 hours IV (recombinant); 24–36 hours for urinary hCG depending on formulation

Dosage range

500-1500 IU subcutaneously 2-3x weekly (clinical context)

Administration

Subcutaneous injection

Research level

Strong

How HCG works

HCG binds luteinizing hormone/choriogonadotropin receptors (LHCGR) on Leydig cells in the testes, stimulating cAMP-mediated testosterone biosynthesis through the cholesterol side-chain cleavage pathway. In women, it triggers ovulation by mimicking the LH surge. Its use alongside or following anabolic androgenic steroid cycles is common to prevent testicular atrophy and preserve endogenous testosterone production.

Also known as: Human Chorionic Gonadotropin, Pregnyl, Novarel, hCG

Research relevance

Sexual Health
Moderate relevance 60

Side effects & safety

Gynecomastia Testicular pain Acne Water retention Mood changes

Contraindications

Androgen-sensitive cancer
Precocious puberty
Uncontrolled thyroid disorder

Consult a healthcare provider before use if any of these apply to you.

Key studies

FAQ

What is HCG? +
Human Chorionic Gonadotropin (HCG) is an FDA-approved glycoprotein hormone used clinically to stimulate testosterone production in hypogonadal men, support fertility in women, and maintain testicular function during or after androgen therapy. It mimics luteinizing hormone (LH) at the gonadal level. Its mechanism of action is supported by robust clinical evidence.
What is HCG researched for? +
HCG has the strongest research relevance for Sexual Health. Evidence is supported by robust clinical evidence.
What are the side effects of HCG? +
Reported side effects include Gynecomastia, Testicular pain, Acne, Water retention, Mood changes. Key contraindications: Androgen-sensitive cancer; Precocious puberty; Uncontrolled thyroid disorder.
Is HCG FDA approved? +
Yes, HCG has FDA approval for specific indications. Always consult a healthcare provider for appropriate use.
How is HCG administered? +
HCG is typically administered via subcutaneous route. Researched dosage range: 500-1500 IU subcutaneously 2-3x weekly (clinical context). Half-life: Approximately 29 hours SC, 26.5 hours IV (recombinant); 24–36 hours for urinary hCG depending on formulation.

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