WhatPeptide

Hexarelin

Hexarelin is a synthetic hexapeptide GHRP and one of the most potent GH secretagogues, also studied for cardioprotective properties through ghrelin receptor-independent mechanisms. It demonstrates GH-releasing activity comparable to GHRP-6 but with distinct cardiovascular effects observed in animal models.

Moderate evidence Unregulated Growth Hormone Releasing Peptide

Written by WhatPeptide Editorial Team · Last updated 2026-03-17

Half-life

Approximately 70 minutes

Dosage range

100-200 mcg subcutaneously 1-3x daily (published research context)

Administration

Subcutaneous injection

Research level

Moderate

How Hexarelin works

Hexarelin primarily activates the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus to stimulate pulsatile GH release, while simultaneously engaging CD36 scavenger receptors in cardiac tissue to exert cardioprotective and anti-ischemic effects independent of GH secretion. Its high potency relative to other GHRPs is attributed to favorable receptor binding kinetics and resistance to peptidase degradation. Long-term use leads to somatotroph desensitization, limiting continuous administration protocols.

Also known as: Examorelin, EP-23905, MF-6003

Research relevance

GH Boost
Strong research relevance 80
Muscle Growth
Moderate relevance 65

Side effects & safety

Increased cortisol and prolactin Water retention Increased appetite Injection site irritation Elevated IGF-1 — theoretical concern for cancer promotion with prolonged use Possible insulin resistance with chronic use

Contraindications

Active malignancy
Diabetic retinopathy
Pregnancy
Acromegaly

Consult a healthcare provider before use if any of these apply to you.

Key studies

FAQ

What is Hexarelin? +
Hexarelin is a synthetic hexapeptide GHRP and one of the most potent GH secretagogues, also studied for cardioprotective properties through ghrelin receptor-independent mechanisms. It demonstrates GH-releasing activity comparable to GHRP-6 but with distinct cardiovascular effects observed in animal models. Its mechanism of action is supported by moderate clinical and preclinical evidence.
What is Hexarelin researched for? +
Hexarelin has the strongest research relevance for GH Boost, Muscle Growth. Evidence is supported by moderate clinical and preclinical evidence.
What are the side effects of Hexarelin? +
Reported side effects include Increased cortisol and prolactin, Water retention, Increased appetite, Injection site irritation, Elevated IGF-1 — theoretical concern for cancer promotion with prolonged use, Possible insulin resistance with chronic use. Key contraindications: Active malignancy; Diabetic retinopathy; Pregnancy; Acromegaly.
Is Hexarelin FDA approved? +
Hexarelin is not FDA-approved. It is available as a research compound or through compounding pharmacies in some jurisdictions.
How is Hexarelin administered? +
Hexarelin is typically administered via subcutaneous route. Researched dosage range: 100-200 mcg subcutaneously 1-3x daily (published research context). Half-life: Approximately 70 minutes.

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