WhatPeptide

Mazdutide

Mazdutide is a once-weekly dual GLP-1 receptor and glucagon receptor co-agonist in late-stage clinical development for obesity and type 2 diabetes, showing significant weight loss in Phase 3 trials predominantly conducted in the Asia-Pacific region. The glucagon component adds hepatic fat mobilization and energy expenditure to GLP-1-mediated appetite suppression.

Moderate evidence Investigational GLP-1/Glucagon Agonist

Written by WhatPeptide Editorial Team · Last updated 2026-03-17

Currently in clinical trials — not yet approved for any indication.

Half-life

Approximately 7 days

Dosage range

3-9 mg once weekly (phase 3 dosing)

Administration

Subcutaneous injection

Research level

Moderate

How Mazdutide works

Mazdutide simultaneously activates GLP-1 receptors to reduce appetite, slow gastric emptying, and enhance glucose-dependent insulin secretion, while glucagon receptor agonism increases hepatic glucose output, thermogenesis, and lipolysis. The complementary mechanisms allow weight loss that exceeds pure GLP-1 monotherapy, with Phase 3 data reporting approximately 18-20% body weight reduction. The glucagon component requires careful dose titration to avoid hyperglycemia risk.

Also known as: IBI362, LY3305677, Dual GLP-1/glucagon agonist

Clinical trial efficacy

GLORY-1 Phase 3: -12.1% (4 mg) / -14.8% (6 mg) body weight at 48 weeks in a Chinese population.

Research relevance

Fat Loss
Strong research relevance 90

Side effects & safety

Nausea Vomiting Diarrhea Decreased appetite Injection site reactions Pancreatitis (rare but serious) Thyroid C-cell tumors (boxed warning — rodent signal, human relevance uncertain) Potential lean mass loss alongside fat loss

Contraindications

History of medullary thyroid carcinoma
MEN2
Pregnancy
Severe gastrointestinal disease

Consult a healthcare provider before use if any of these apply to you.

Key studies

FAQ

What is Mazdutide? +
Mazdutide is a once-weekly dual GLP-1 receptor and glucagon receptor co-agonist in late-stage clinical development for obesity and type 2 diabetes, showing significant weight loss in Phase 3 trials predominantly conducted in the Asia-Pacific region. The glucagon component adds hepatic fat mobilization and energy expenditure to GLP-1-mediated appetite suppression. Its mechanism of action is supported by moderate clinical and preclinical evidence.
What is Mazdutide researched for? +
Mazdutide has the strongest research relevance for Fat Loss. Evidence is supported by moderate clinical and preclinical evidence.
What are the side effects of Mazdutide? +
Reported side effects include Nausea, Vomiting, Diarrhea, Decreased appetite, Injection site reactions, Pancreatitis (rare but serious), Thyroid C-cell tumors (boxed warning — rodent signal, human relevance uncertain), Potential lean mass loss alongside fat loss. Key contraindications: History of medullary thyroid carcinoma; MEN2; Pregnancy; Severe gastrointestinal disease.
Is Mazdutide FDA approved? +
Mazdutide is currently in clinical trials and is not yet approved by the FDA.
How is Mazdutide administered? +
Mazdutide is typically administered via subcutaneous route. Researched dosage range: 3-9 mg once weekly (phase 3 dosing). Half-life: Approximately 7 days.

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