WhatPeptide

Pinealon

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) derived from the pineal gland, studied for neuroprotective effects, circadian rhythm regulation, and cognitive performance in animal models and limited clinical observations in Eastern European research. It is related to the family of short peptide bioregulators developed by the St. Petersburg Institute of Bioregulation.

Preliminary evidence Unregulated Nootropic

Written by WhatPeptide Editorial Team · Last updated 2026-03-17

Half-life

Short; route-dependent

Dosage range

1-5 mg orally daily in cycles (based on bioregulator research protocols)

Administration

Oral

Research level

Preliminary

How Pinealon works

Pinealon is proposed to penetrate the blood-brain barrier and interact directly with neuronal nuclear chromatin, modulating gene expression in neurons involved in circadian regulation and neuroprotection. In animal and cell culture studies, it reduces neuronal apoptosis under hypoxic conditions and supports melatonin synthesis pathways in the pineal gland. Its oral bioavailability, while limited by peptidase activity, may be sufficient for some CNS effects due to its very small size.

Also known as: EDR peptide, Epithalon-related peptide, Glu-Asp-Arg

Research relevance

Sleep & Relaxation
Moderate relevance 60
Cognition & Focus
Moderate relevance 55

Side effects & safety

Generally well tolerated in reported use Limited safety data available

Contraindications

Pregnancy
No established human safety profile outside Eastern European research

Consult a healthcare provider before use if any of these apply to you.

Key studies

FAQ

What is Pinealon? +
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) derived from the pineal gland, studied for neuroprotective effects, circadian rhythm regulation, and cognitive performance in animal models and limited clinical observations in Eastern European research. It is related to the family of short peptide bioregulators developed by the St. Petersburg Institute of Bioregulation. Its mechanism of action is based on preliminary or early-stage research.
What is Pinealon researched for? +
Pinealon has the strongest research relevance for Sleep & Relaxation, Cognition & Focus. Evidence is based on preliminary or early-stage research.
What are the side effects of Pinealon? +
Reported side effects include Generally well tolerated in reported use, Limited safety data available. Key contraindications: Pregnancy; No established human safety profile outside Eastern European research.
Is Pinealon FDA approved? +
Pinealon is not FDA-approved. It is available as a research compound or through compounding pharmacies in some jurisdictions.
How is Pinealon administered? +
Pinealon is typically administered via oral route. Researched dosage range: 1-5 mg orally daily in cycles (based on bioregulator research protocols). Half-life: Short; route-dependent.

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