WhatPeptide

Selank

A synthetic tuftsin-derived peptide studied for anxiolytic and cognitive effects, typically via intranasal delivery. Was placed on FDA Category 2 list (September 2023 – September 2024) before being removed when the nominator withdrew. FDA continues to flag safety concerns under a separate listing.

Moderate evidence Unregulated Nootropic

Written by WhatPeptide Editorial Team · Last updated 2026-03-17

Half-life

Short plasma half-life; central effects may outlast dosing

Dosage range

250-1000 mcg/day intranasal divided doses (published research context)

Administration

Intranasal

Research level

Moderate

How Selank works

Selank appears to modulate GABAergic and serotonergic signaling while also affecting cytokine expression in preclinical models. It is investigated for anxiolytic and attention-related effects without classic sedative burden. Human data remains limited and concentrated in small regional studies.

Also known as: Tuftsin analog, Heptapeptide Selank

Research relevance

Cognition & Focus
Moderate relevance 75
Sleep & Relaxation
Moderate relevance 60
Immune Support
Moderate relevance 50
Recovery & Healing
Some relevance 20
Anti-Aging & Longevity
Some relevance 20

Side effects & safety

Nasal irritation Fatigue Headache

Contraindications

Pregnancy
Severe mood disorders without supervision

Consult a healthcare provider before use if any of these apply to you.

Key studies

FAQ

What is Selank? +
A synthetic tuftsin-derived peptide studied for anxiolytic and cognitive effects, typically via intranasal delivery. Was placed on FDA Category 2 list (September 2023 – September 2024) before being removed when the nominator withdrew. FDA continues to flag safety concerns under a separate listing. Its mechanism of action is supported by moderate clinical and preclinical evidence.
What is Selank researched for? +
Selank has the strongest research relevance for Cognition & Focus, Sleep & Relaxation, Immune Support. Evidence is supported by moderate clinical and preclinical evidence.
What are the side effects of Selank? +
Reported side effects include Nasal irritation, Fatigue, Headache. Key contraindications: Pregnancy; Severe mood disorders without supervision.
Is Selank FDA approved? +
Selank is not FDA-approved. It is available as a research compound or through compounding pharmacies in some jurisdictions.
How is Selank administered? +
Selank is typically administered via nasal route. Researched dosage range: 250-1000 mcg/day intranasal divided doses (published research context). Half-life: Short plasma half-life; central effects may outlast dosing.

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